Santa Ana Vacation Packages 2026 from $752

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Your Santa Ana Vacation

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.

The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Decapolis Hotel Panama City

San Francisco

$752

per person

Oct 30 - Nov 6

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

8.6/10 Excellent! (1,708 reviews)

Central Hotel Panama Casco Viejo

Casco Viejo

$1,124

per person

Nov 26 - Dec 2

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

9/10 Wonderful! (1,012 reviews)

Such a great experience! I’d recommend it to anyone and love to stay again.

Reviewed on Sep 20, 2026

Megapolis Hotel Panamá

San Francisco

Save 100% on your flight

$891

per person

Nov 26 - Dec 2

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

8.4/10 Very Good! (1,693 reviews)

The pool Is on maintenance, my room had 2 water bottles one was open already I called so they could change it but it never happened. Also the toilet had a stain it look like not watched properly.

Reviewed on Sep 20, 2026

Riande Aeropuerto Hotel & Casino

Tocumen Airport

$844

per person

Nov 26 - Dec 2

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

8.6/10 Excellent! (1,811 reviews)

Clean room and

Reviewed on Sep 21, 2026

Hotel Riu Plaza Panama

Bella Vista

$871

per person

Nov 26 - Dec 2

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

9/10 Wonderful! (5,892 reviews)

I spent my honeymoon and was greeted with champagne and an assorted dish of chocolate-covered strawberries and other goodies. The room was very spacious and clean excellent breakfast and the Resturants were convenient with a wide assortments I will definitely stay here again and recommend the Riu. It

Reviewed on Sep 21, 2026

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana

A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A cityscape with modern skyscrapers, including a distinctive twisting tower.

Bella Vista

1 out of top 10 points of interest in this area

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Santa Ana Hotel Deals

Hotel Caracas - Casco Viejo

Plaza De Santa Ana Panama City Provincia di Panama

Fully refundableReserve now, pay when you stay

$37 nightly

$41 total

Oct 14 - Oct 15

Total with taxes and fees

Casco View Apartments

C. 16 Oeste Panama City Provincia de Panamá

$83 nightly

$91 total

Sep 23 - Sep 24

Total with taxes and fees

9/10 Wonderful! (106 reviews)

"We really enjoyed our stay at Casco View. It was an easy walk into Casca Viejo and centrally located. The host uses a guesty app to provide room details, apartment codes, etc, so it was a really easy and smooth process to get checked in. The room itself was very clean and well appointed. We stayed ..."

Reviewed on Sep 8, 2026

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

$138 nightly

$151 total

Sep 28 - Sep 29

Total with taxes and fees

9/10 Wonderful! (5,972 reviews)

"I spent my honeymoon and was greeted with champagne and an assorted dish of chocolate-covered strawberries and other goodies. The room was very spacious and clean excellent breakfast and the Resturants were convenient with a wide assortments I will definitely stay here again and recommend the Riu. ..."

Reviewed on Sep 21, 2026

See all 1,781 properties in Santa Ana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.